Prevention RFP — Alzheimer's Drug Discovery Foundation

About this program

The Alzheimer's Drug Discovery Foundation (ADDF) offers grants of up to $5,000,000 to support precision prevention studies, combination therapy research, and comparative effectiveness studies aimed at reducing the risk of Alzheimer's disease and related dementias. Focus areas include primary and secondary prevention in clinical populations with specific risk factors, such as APOE4 genotype, hypertension, and diabetes, with a requirement for human subject involvement.

Applicants must be researchers or clinicians from academic medical centers, universities, nonprofits, or biotechnology companies worldwide, with industry partnerships encouraged. Proposals should include strong biological rationale, preliminary data, and clear mechanisms of action, with clinical trial submissions requiring detailed study design, biomarker outcomes, and recruitment plans.