PCORI Funding Announcement: Retrospective Observational Comparative Clinical Effectiveness Research (Cycle 1 2026)

About this program

The Patient-Centered Outcomes Research Institute (PCORI) offers a grant opportunity for retrospective observational studies, aiming to enhance healthcare decision-making and patient outcomes. Researchers are invited to propose studies focusing on comparative clinical effectiveness research (CER) in specific health areas, leveraging existing data sources like PCORnet. Applicants must address decisional dilemmas, compare interventions with strong evidence, and propose clinically significant outcomes. PCORI encourages the use of advanced causal inference methods and data from diverse health systems. The grant supports studies with up to $2 million in direct costs, but does not fund new data networks or patient registries.